(S)-tert-Butyl 2-(phenoxymethyl)pyrrolidine-1-carboxylate → (S)-tert-Butyl 2-(phenoxymethyl)azetidine-1-carboxylate

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Reaction Steps

(S)-tert-Butyl 2-(phenoxymethyl)azetidine-1-carboxylate (16) was prepared according to the same procedure for compound 9, except using compound 15, and purified with hexanes-ether (2:1) to afford 0.81 g (79%) of 16 as a colorless oil. 1H NMR (300 MHz, CDCl3) δ CDCl3 7.30 (m, 2H), 6.94 (m, 3H), 4.53 (m, 1H), 4.26 (m, 1H), 4.12 (m, 1H), 3.93 (m, 2H), 2.33 (m, 2H), 1.43 (s, 9H).

Provenance & Evidence