反应详情

温度

50 °C

In a 25 mL round-bottomed flask [1-(1-hydroxy-1-methyl-ethyl)-cyclopentyl]-carbamic acid tert-butyl ester (0.31 g, 1.27 mmol) was dissolved in 1.0 M HCl solution in MeOH (8.2 mL, 8.2 mmol). The reaction mixture was stirred at 50° C. for 4 h then cooled to room temperature and concentrated under reduced pressure to afford 0.23 g (96%) of 2-(1-amino-cyclopentyl)-propan-2-ol hydrochloride as an off-white foam which was used without further purification.

1. temperaturethen cooled to room temperature
2. concentrationconcentrated under reduced pressure