Hydrochloric Acid → HCID 67001422, compound

HRID 2191558Notes

Reaction equation

C(OC(=O)[NH:7][C:8]1([C:13]([OH:16])([CH3:15])[CH3:14])[CH2:12][CH2:11][CH2:10][CH2:9]1)(C)(C)C.CO.[ClH:20]>>[ClH:20].[NH2:7][C:8]1([C:13]([OH:16])([CH3:15])[CH3:14])[CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 67002055HCID 67002055, compound

Product 1

HCID 67001422HCID 67001422, compoundYield 96%

Conditions

Temperature: 50 °C

Procedure

In a 25 mL round-bottomed flask [1-(1-hydroxy-1-methyl-ethyl)-cyclopentyl]-carbamic acid tert-butyl ester (0.31 g, 1.27 mmol) was dissolved in 1.0 M HCl solution in MeOH (8.2 mL, 8.2 mmol). The reaction mixture was stirred at 50° C. for 4 h then cooled to room temperature and concentrated under reduced pressure to afford 0.23 g (96%) of 2-(1-amino-cyclopentyl)-propan-2-ol hydrochloride as an off-white foam which was used without further purification.

Workup

temperaturethen cooled to room temperature
concentrationconcentrated under reduced pressure

Sources & evidence

ORD record: ord-7dd143a7ba7c462e996bddba95b015e8
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08329699B2

Reaction notes

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