Hydrochloric Acid → HCID 67001988, compound

HRID 2191588Notes

Reaction equation

HRID 2191588 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:12][CH2:11][O:10][C:9]1([CH3:14])[CH3:13])(C)(C)C.[ClH:16]>CO>[ClH:16].[CH3:13][C:9]1([CH3:14])[CH:8]([NH2:7])[CH2:12][CH2:11][O:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67002293HCID 67002293, compound

Product 1

HCID 67001988HCID 67001988, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(2,2-Dimethyl-tetrahydro-furan-3-yl)-carbamic acid tert-butyl ester (266 mg, 1.10 mmol) was dissolved in a solution of HCl in MeOH (pre-generated from MeOH (8 mL) and acetyl chloride (2 mL)) and stirred at room temperature overnight. The reaction mixture was concentrated to afford 193 mg of 2,2-dimethyl-tetrahydrofuran-3-ylamine hydrochloride as a hydroscopic white solid which was used without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-69e054583ef74f42be359af201657a76
Source dataset
uspto-grants-2012_12
Patent number
US08329699B2

Reaction notes

Loading…