反应详情

To a mixed solution of methanol 22 mL and ethyl acetate 22 mL of tert-butyl 4-((E)-2-(3-methoxyphenyl)vinyl)-2-nitrobenzoate 2.2 g was added 10% palladium-carbon 0.66 g, and it was stirred under hydrogen atmosphere at room temperature for 2 hours. The solvent was removed under reduced pressure after insoluble matter was filtrated. The obtained residue was refined by silica gel column chromatography [Fuji SILYSIA Chemical Ltd., PSQ100B(spherical type), eluent; hexane:ethyl acetate=8:1] to give tert-butyl 2-amino-4-(2-(3-methoxyphenyl)ethyl)benzoate 1.6 g of colorless oil.

1. customThe solvent was removed under reduced pressure after insoluble matter
2. filtrationwas filtrated