HCID 68960022, compound → HCID 68962909, compound

HRID 2191657Notes

Reaction equation

HRID 2191657 reaction equation
[C:1]([NH:4][C:5]1[CH:6]=[C:7]([C:11]2[CH:23]=[CH:22][C:14]([C:15]([O:17]C(C)(C)C)=[O:16])=[C:13]([NH:24][C:25]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=3)[CH:12]=2)[CH:8]=[CH:9][CH:10]=1)(=[O:3])[CH3:2]>FC(F)(F)C(O)=O>[C:1]([NH:4][C:5]1[CH:6]=[C:7]([C:11]2[CH:23]=[CH:22][C:14]([C:15]([OH:17])=[O:16])=[C:13]([NH:24][C:25]3[CH:26]=[CH:27][C:28]([F:31])=[CH:29][CH:30]=3)[CH:12]=2)[CH:8]=[CH:9][CH:10]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 68960022HCID 68960022, compound

Product 1

HCID 68962909HCID 68962909, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Trifluoroacetic acid 10 mL was added to the obtained tert-butyl 4-(3-(acetamido)phenyl)-2-(4-fluoroanilino)benzoate, and it was stirred at room temperature for 1 hour. The solvent was removed under reduced pressure, methanol was added to the obtained residue, and solid matter was filtrated to give 4-(3-(acetamido)phenyl)-2-(4-fluoroanilino)benzoic acid 32 mg of pale yellow solid.

Workup

  1. customThe solvent was removed under reduced pressure, methanol
  2. additionwas added to the obtained residue, and solid matter
  3. filtrationwas filtrated

Sources & evidence

ORD record
ord-76caeb1e12ce4e13a1468cb7c384bb5e
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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