HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-(Benzothiophene-3-carboxamido)-2-(4-fluoroanilino)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 4-(benzothiophene-3-carboxamido)-2-(4-fluoroanilino)benzoate | HCID 68959063 | — |
| Product | 4-(Benzothiophene-3-carboxamido)-2-(4-fluoroanilino)benzoic acid | HCID 57667976 | — |
Reaction Steps
Trifluoroacetic acid 5 mL was added to the obtained tert-butyl 4-(benzothiophene-3-carboxamido)-2-(4-fluoroanilino)benzoate, and it was stirred at room temperature for 1 hour. The solvent was removed under reduced pressure,diisopropyl ether was added to the obtained residue, and solid matter was filtrated to give 4-(benzothiophene-3-carboxamido)-2-(4-fluoroanilino)benzoic acid 24 mg of white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08327467B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-af9d798f9cda474196b97b1ec0fd66be |
| Source note | uspto-grants-2012_12 |