Trifluoroacetic acid → 4-(Benzothiophene-3-carboxamido)-2-(4-fluoroanilino)benzoic acid

HRID 2191700Notes

Reaction equation

HRID 2191700 reaction equation
FC(F)(F)C(O)=O.[S:8]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10]([C:17]([NH:19][C:20]2[CH:32]=[CH:31][C:23]([C:24]([O:26]C(C)(C)C)=[O:25])=[C:22]([NH:33][C:34]3[CH:39]=[CH:38][C:37]([F:40])=[CH:36][CH:35]=3)[CH:21]=2)=[O:18])=[CH:9]1>>[S:8]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10]([C:17]([NH:19][C:20]2[CH:32]=[CH:31][C:23]([C:24]([OH:26])=[O:25])=[C:22]([NH:33][C:34]3[CH:35]=[CH:36][C:37]([F:40])=[CH:38][CH:39]=3)[CH:21]=2)=[O:18])=[CH:9]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68959063Tert-butyl 4-(benzothiophene-3-carboxamido)-2-(4-fluoroanilino)benzoate

Product 1

HCID 576679764-(Benzothiophene-3-carboxamido)-2-(4-fluoroanilino)benzoic acid

Procedure

Trifluoroacetic acid 5 mL was added to the obtained tert-butyl 4-(benzothiophene-3-carboxamido)-2-(4-fluoroanilino)benzoate, and it was stirred at room temperature for 1 hour. The solvent was removed under reduced pressure,diisopropyl ether was added to the obtained residue, and solid matter was filtrated to give 4-(benzothiophene-3-carboxamido)-2-(4-fluoroanilino)benzoic acid 24 mg of white solid.

Workup

  1. customThe solvent was removed under reduced pressure,diisopropyl ether
  2. additionwas added to the obtained residue, and solid matter
  3. filtrationwas filtrated

Sources & evidence

ORD record
ord-af9d798f9cda474196b97b1ec0fd66be
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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