Trifluoroacetic acid → HCID 57668075, compound

HRID 2191708Notes

Reaction equation

HRID 2191708 reaction equation
FC(F)(F)C(O)=O.[NH:8]([C:15]1[CH:27]=[C:26]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:25]=[CH:24][C:16]=1[C:17]([O:19]C(C)(C)C)=[O:18])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[NH:8]([C:15]1[CH:27]=[C:26]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:25]=[CH:24][C:16]=1[C:17]([OH:19])=[O:18])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68961626HCID 68961626, compound

Product 1

HCID 57668075HCID 57668075, compound

Procedure

Trifluoroacetic acid 3.0 mL solution of the obtained tert-butyl 2-anilino-4-phenylbenzoate was stirred at room temperature for 3 hours. The solvent of reaction mixture was removed under reduced pressure, and the obtained residue was refined by silica gel column chromatography [Trikonex company, Flash Tube 2008, eluent; hexane:ethyl acetate:acetic acid=30:10:1] to give 2-anilino-4-phenylbenzoic acid 8 mg of pale yellow solid.

Workup

  1. customThe solvent of reaction mixture
  2. customwas removed under reduced pressure

Sources & evidence

ORD record
ord-71ab7faf982444d89ee031fef24a6073
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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