Trifluoroacetic acid → HCID 57668076, compound

HRID 2191716Notes

Reaction equation

HRID 2191716 reaction equation
FC(F)(F)C(O)=O.[OH:8][C:9]1[CH:10]=[C:11]([NH:15][C:16]2[CH:28]=[C:27]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH:26]=[CH:25][C:17]=2[C:18]([O:20]C(C)(C)C)=[O:19])[CH:12]=[CH:13][CH:14]=1>>[OH:8][C:9]1[CH:10]=[C:11]([NH:15][C:16]2[CH:28]=[C:27]([C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)[CH:26]=[CH:25][C:17]=2[C:18]([OH:20])=[O:19])[CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68961645HCID 68961645, compound

Product 1

HCID 57668076HCID 57668076, compound

Procedure

Trifluoroacetic acid 5.0 mL solution of the obtained tert-butyl 2-((3-hydroxyphenyl)amino)-4-phenylbenzoate was stirred at room temperature for 3 hours. The solvent was removed under reduced pressure, hexane and diisopropyl ether were added to obtained residue, solid matter was filtrated to give 2-((3-hydroxyphenyl)amino)-4-phenylbenzoic acid 15 mg of yellow solid.

Workup

  1. customThe solvent was removed under reduced pressure, hexane and diisopropyl ether
  2. additionwere added
  3. customto obtained residue, solid matter
  4. filtrationwas filtrated

Sources & evidence

ORD record
ord-099abf55993d496cb2031d3a7290aa4c
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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