Trifluoroacetic acid → HCID 57668031, compound

HRID 2191720Notes

Reaction equation

HRID 2191720 reaction equation
FC(F)(F)C(O)=O.[CH:8]1(/[CH:14]=[CH:15]/[C:16]2[CH:28]=[CH:27][C:19]([C:20]([O:22]C(C)(C)C)=[O:21])=[C:18]([NH:29][C:30]3[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=3)[CH:17]=2)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1>>[CH:8]1(/[CH:14]=[CH:15]/[C:16]2[CH:28]=[CH:27][C:19]([C:20]([OH:22])=[O:21])=[C:18]([NH:29][C:30]3[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=3)[CH:17]=2)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68958957HCID 68958957, compound

Product 1

HCID 57668031HCID 57668031, compound

Procedure

Trifluoroacetic acid 15 mL solution of the obtained tert-butyl 4-((E)-2-cyclohexylvinyl)-2-(4-fluoroanilino)benzoate was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure to give 4-((E)-2-cyclohexylvinyl)-2-(4-fluoroanilino)benzoic acid 34 mg of pale yellow solid.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-14febcd9a05d4db09ed787f9becd6af8
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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