Trifluoroacetic acid → HCID 57668030, compound

HRID 2191732Notes

Reaction equation

FC(F)(F)C(O)=O.[F:8][C:9]1[CH:40]=[CH:39][C:12]([NH:13][C:14]2[CH:26]=[C:25](/[CH:27]=[CH:28]/[C:29]3[CH:34]=[CH:33][C:32]([C:35]([F:38])([F:37])[F:36])=[CH:31][CH:30]=3)[CH:24]=[CH:23][C:15]=2[C:16]([O:18]C(C)(C)C)=[O:17])=[CH:11][CH:10]=1>>[F:8][C:9]1[CH:10]=[CH:11][C:12]([NH:13][C:14]2[CH:26]=[C:25](/[CH:27]=[CH:28]/[C:29]3[CH:34]=[CH:33][C:32]([C:35]([F:36])([F:37])[F:38])=[CH:31][CH:30]=3)[CH:24]=[CH:23][C:15]=2[C:16]([OH:18])=[O:17])=[CH:39][CH:40]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 68959435HCID 68959435, compound

Product 1

HCID 57668030HCID 57668030, compound

Procedure

Trifluoroacetic acid 15 mL solution of the obtained tert-butyl 2-(4-fluoroanilino)-4-((E)-2-(4-trifluoromethylphenyl)vinyl)benzoate was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure to give 2-(4-fluoroanilino)-4-((E)-2-(4-trifluoromethylphenyl)vinyl)benzoic acid 50 mg of pale yellow solid.

Workup

customThe solvent was removed under reduced pressure

Sources & evidence

ORD record: ord-9a19e23d4b434568b37e24aaf8cbae7c
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08327467B2

Reaction notes

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