HCID 68962514, compound → HCID 57667898, compound

HRID 2191741Notes

Reaction equation

HRID 2191741 reaction equation
[Cl:1][C:2]1[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[C:3]=1[NH:4][C:5]1[CH:17]=[C:16]([CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:15]=[CH:14][C:6]=1[C:7]([O:9]C(C)(C)C)=[O:8]>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[C:3]=1[NH:4][C:5]1[CH:17]=[C:16]([CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:15]=[CH:14][C:6]=1[C:7]([OH:9])=[O:8]

Participants

3

Reactant 1

HCID 68962514HCID 68962514, compound

Product 1

HCID 57667898HCID 57667898, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Trifluoroacetic acid 10 mL was added to the obtained tert-butyl 2-(2,6-dichloroanilino)-4-phenethylbenzoate, and it was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure, and the obtained residue was refined by reversed-phase silica gel column chromatography [eluent; 75-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to give 2-(2,6-dichloroanilino)-4-phenethylbenzoic acid 9.4 mg of white solid.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-9c41f9b1f154426eb3f278547f79cfea
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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