Tert-butyl 2-(4-methylanilino)-4-phenylbenzoate → HCID 57668000, compound

HRID 2191746Notes

Reaction equation

HRID 2191746 reaction equation
[CH3:1][C:2]1[CH:27]=[CH:26][C:5]([NH:6][C:7]2[CH:19]=[C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:17]=[CH:16][C:8]=2[C:9]([O:11]C(C)(C)C)=[O:10])=[CH:4][CH:3]=1>FC(F)(F)C(O)=O>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH:6][C:7]2[CH:19]=[C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:17]=[CH:16][C:8]=2[C:9]([OH:11])=[O:10])=[CH:26][CH:27]=1

Participants

3

Reactant 1

HCID 68960037Tert-butyl 2-(4-methylanilino)-4-phenylbenzoate

Product 1

HCID 57668000HCID 57668000, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Trifluoroacetic acid 10 mL was added to the obtained tert-butyl 2-(4-methylanilino)-4-phenylbenzoate, and it was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure,diisopropyl ether was added to the obtained residue, and solid matter was filtrated to give 2-(4-methylanilino)-4-phenylbenzoic acid 8.7 mg of white solid.

Workup

  1. customThe solvent was removed under reduced pressure,diisopropyl ether
  2. additionwas added to the obtained residue, and solid matter
  3. filtrationwas filtrated

Sources & evidence

ORD record
ord-4734aff2a3564790855113a45c2cbfcd
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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