反应详情

Trifluoroacetic acid 5.0 mL was added to the obtained tert-butyl 2-(4-fluoroanilino)-4-(2-isopropoxyphenyl)benzoate, and it was stirred at room temperature for 3 hours. The solvent was removed under reduced pressure, and the obtained residue was refined by reversed-phase silica gel column chromatography [eluent; 80-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to give 2-(4-fluoroanilino)-4-(2-isopropoxyphenyl)benzoic acid 16 mg of a white solid.

1. customThe solvent was removed under reduced pressure