Trifluoroacetic acid → HCID 68956439, compound

HRID 2191773Notes

Reaction equation

HRID 2191773 reaction equation
FC(F)(F)C(O)=O.[NH2:8][S:9]([C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:30]=[CH:29][C:21]([C:22]([O:24]C(C)(C)C)=[O:23])=[C:20]([NH:31][C:32]3[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=3)[CH:19]=2)=[CH:14][CH:13]=1)(=[O:11])=[O:10]>>[NH2:8][S:9]([C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:30]=[CH:29][C:21]([C:22]([OH:24])=[O:23])=[C:20]([NH:31][C:32]3[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=3)[CH:19]=2)=[CH:14][CH:13]=1)(=[O:11])=[O:10]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68964078HCID 68964078, compound

Product 1

HCID 68956439HCID 68956439, compound

Procedure

Trifluoroacetic acid 3.0 mL solution of the obtained tert-butyl 4-(4-(aminosulfonyl)phenyl)-2-(4-fluoroanilino)benzoate was stirred at room temperature for 30 minutes. The solvent was removed under reduced pressure,diisopropyl ether was added to the obtained residue, and solid matter was filtrated to give 4-(4-(aminosulfonyl)phenyl)-2-(4-fluoroanilino)benzoic acid 20 mg of a pale yellow solid.

Workup

  1. customThe solvent was removed under reduced pressure,diisopropyl ether
  2. additionwas added to the obtained residue, and solid matter
  3. filtrationwas filtrated

Sources & evidence

ORD record
ord-26d505dd85074cf19c6177d4e014b8ab
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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