Trifluoroacetic acid → HCID 68965111, compound

HRID 2191781Notes

Reaction equation

[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[N:8]1([C:17]2[CH:29]=[CH:28][C:20]([C:21]([O:23]C(C)(C)C)=[O:22])=[C:19]([NH:30][C:31]3[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=3)[CH:18]=2)[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[N:10]=[CH:9]1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[N:8]1([C:17]2[CH:29]=[CH:28][C:20]([C:21]([OH:23])=[O:22])=[C:19]([NH:30][C:31]3[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=3)[CH:18]=2)[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[N:10]=[CH:9]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 68960518HCID 68960518, compound

Product 1

HCID 68965111HCID 68965111, compound

Procedure

Trifluoroacetic acid 7.5 mL solution of tert-butyl 4-(1H-benzimidazol-1-yl)-2-(4-fluoroanilino)benzoate 0.16 g was stirred at room temperature for 1 hour and 30 minutes. The solvent was removed under reduced pressure, ethyl acetate was added to the obtained residue, and solid matter was filtrated to give 4-(1H-benzimidazol-1-yl)-2-(4-fluoroanilino)benzoic acid trifluoroacetate 99 mg of a yellow solid.

Workup

customThe solvent was removed under reduced pressure, ethyl acetate
additionwas added to the obtained residue, and solid matter
filtrationwas filtrated

Sources & evidence

ORD record: ord-33747eaddadb4d3cabc78ca8fe0d8a05
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08327467B2

Reaction notes

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