HCID 68960003, compound → HCID 57667989, compound

Participants

Reaction Steps

Trifluoroacetic acid 10 mL solution of the obtained tert-butyl 4-((E)-2-(2-chlorophenyl)vinyl)-2-(4-fluoroanilino)benzoate was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure, the obtained residue was refined by reversed-phase silica gel column chromatography [eluent; 85-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to give 4-((E)-2-(2-chlorophenyl)vinyl)-2-(4-fluoroanilino)benzoic acid 4.6 mg of a yellow solid.

Provenance & Evidence