HCID 68960003, compound → HCID 57667989, compound

HRID 2191782Notes

Reaction equation

HRID 2191782 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1/[CH:8]=[CH:9]/[C:10]1[CH:22]=[CH:21][C:13]([C:14]([O:16]C(C)(C)C)=[O:15])=[C:12]([NH:23][C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[CH:11]=1>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1/[CH:8]=[CH:9]/[C:10]1[CH:22]=[CH:21][C:13]([C:14]([OH:16])=[O:15])=[C:12]([NH:23][C:24]2[CH:25]=[CH:26][C:27]([F:30])=[CH:28][CH:29]=2)[CH:11]=1

Participants

3

Reactant 1

HCID 68960003HCID 68960003, compound

Product 1

HCID 57667989HCID 57667989, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Trifluoroacetic acid 10 mL solution of the obtained tert-butyl 4-((E)-2-(2-chlorophenyl)vinyl)-2-(4-fluoroanilino)benzoate was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure, the obtained residue was refined by reversed-phase silica gel column chromatography [eluent; 85-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to give 4-((E)-2-(2-chlorophenyl)vinyl)-2-(4-fluoroanilino)benzoic acid 4.6 mg of a yellow solid.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-42ae2e4d731b46c381a0a3f3a72adfbe
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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