反应详情

Acetic acid 2.0 mL,dioxane 2.0 mL and 10% palladium-carbon 37 mg were added to the obtained tert-butyl 2-(4-fluoroanilino)-4-((E)-2-(3-(methanesulfonamido)phenyl)vinyl)benzoate sequentially, and it was stirred under hydrogen atmosphere at room temperature for 5 hours and 30 minutes. The solvent was removed under reduced pressure after insoluble matter was filtrated. Trifluoroacetic acid 10 mL was added to the obtained residue, and it was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure,diisopropyl ether was added to the obtained residue, and solid matter was filtrated to give 2-(4-fluoroanilino)-4-(2-(3-(methanesulfonamido)phenyl)ethyl)benzoic acid 75 mg of a white solid.

1. customThe solvent was removed under reduced pressure after insoluble matter
2. filtrationwas filtrated
3. additionTrifluoroacetic acid 10 mL was added to the obtained residue, and it
4. stirringwas stirred at room temperature for 2 hours
5. customThe solvent was removed under reduced pressure,diisopropyl ether
6. additionwas added to the obtained residue, and solid matter
7. filtrationwas filtrated