HCID 68958430, compound → HCID 57668091, compound

Participants

Reaction Steps

Acetic acid 2.0 mL,dioxane 2.0 mL and 10% palladium-carbon 37 mg were added to the obtained tert-butyl 2-(4-fluoroanilino)-4-((E)-2-(3-(methanesulfonamido)phenyl)vinyl)benzoate sequentially, and it was stirred under hydrogen atmosphere at room temperature for 5 hours and 30 minutes. The solvent was removed under reduced pressure after insoluble matter was filtrated. Trifluoroacetic acid 10 mL was added to the obtained residue, and it was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure,diisopropyl ether was added to the obtained residue, and solid matter was filtrated to give 2-(4-fluoroanilino)-4-(2-(3-(methanesulfonamido)phenyl)ethyl)benzoic acid 75 mg of a white solid.

Provenance & Evidence