Trifluoroacetic acid → HCID 57667846, compound

HRID 2191818Notes

Reaction equation

HRID 2191818 reaction equation
FC(F)(F)C(O)=O.C(OC([O:15][C:16]1[CH:17]=[C:18]([C:22]2[CH:34]=[CH:33][C:25]([C:26]([O:28]C(C)(C)C)=[O:27])=[C:24]([NH:35][C:36]3[CH:41]=[CH:40][CH:39]=[C:38]([OH:42])[CH:37]=3)[CH:23]=2)[CH:19]=[CH:20][CH:21]=1)=O)(C)(C)C>>[OH:15][C:16]1[CH:17]=[C:18]([C:22]2[CH:34]=[CH:33][C:25]([C:26]([OH:28])=[O:27])=[C:24]([NH:35][C:36]3[CH:41]=[CH:40][CH:39]=[C:38]([OH:42])[CH:37]=3)[CH:23]=2)[CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68963254HCID 68963254, compound

Product 1

HCID 57667846HCID 57667846, compound

Procedure

Trifluoroacetic acid 5.0 mL was added to the obtained tert-butyl 4-(3-(tert-butoxycarbonyl)oxyphenyl)-2-((3-hydroxyphenyl)amino)benzoate, and it was stirred at room temperature for 3 hours. The solvent was removed under reduced pressure, hexane and diisopropyl ether were added to the obtained residue, and solid matter was filtrated to give 4-(3-hydroxyphenyl)-2-((3-hydroxyphenyl)amino)benzoic acid 10 mg of a yellow solid.

Workup

  1. customThe solvent was removed under reduced pressure, hexane and diisopropyl ether
  2. additionwere added to the obtained residue, and solid matter
  3. filtrationwas filtrated

Sources & evidence

ORD record
ord-e1be98da4bf4461f8d2f72eaa4f7edd0
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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