Trifluoroacetic acid → HCID 57668043, compound

HRID 2191822Notes

Reaction equation

HRID 2191822 reaction equation
FC(F)(F)C(O)=O.[S:8]1[C:12]2[CH:13]=[CH:14][C:15]([NH:17][C:18]3[CH:30]=[C:29]([C:31]4[CH:36]=[CH:35][CH:34]=[C:33]([O:37]C(OC(C)(C)C)=O)[CH:32]=4)[CH:28]=[CH:27][C:19]=3[C:20]([O:22]C(C)(C)C)=[O:21])=[CH:16][C:11]=2[CH:10]=[CH:9]1>>[S:8]1[C:12]2[CH:13]=[CH:14][C:15]([NH:17][C:18]3[CH:30]=[C:29]([C:31]4[CH:36]=[CH:35][CH:34]=[C:33]([OH:37])[CH:32]=4)[CH:28]=[CH:27][C:19]=3[C:20]([OH:22])=[O:21])=[CH:16][C:11]=2[CH:10]=[CH:9]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68961151HCID 68961151, compound

Product 1

HCID 57668043HCID 57668043, compound

Procedure

Trifluoroacetic acid 5.0 mL was added to the obtained tert-butyl 2-((benzothiophen-5-yl)amino)-4-(3-(tert-butoxycarbonyloxy)phenyl)benzoate, and it was stirred at room temperature for 3 hours. The solvent was removed under reduced pressure,diisopropyl ether was added to the obtained residue, and solid matter was filtrated to give 2-((benzothiophen-5-yl)amino)-4-(3-hydroxyphenyl)benzoic acid 30 mg of a yellow solid.

Workup

  1. customThe solvent was removed under reduced pressure,diisopropyl ether
  2. additionwas added to the obtained residue, and solid matter
  3. filtrationwas filtrated

Sources & evidence

ORD record
ord-0e997bce4a3049cd95659bdc90a794b4
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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