反应详情

Trifluoroacetic acid 10 mL was added to the obtained tert-butyl 2-((3-hydroxyphenyl)amino)-4-(2-(3-methoxyphenyl)ethyl)benzoate, and it was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure, and the obtained residue was refined by reversed-phase silica gel column chromatography [eluent; 50-90% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to give 2-((3-hydroxyphenyl)amino)-4-(2-(3-methoxyphenyl)ethyl)benzoic acid 17 mg of a white solid.

1. customThe solvent was removed under reduced pressure