HCID 68958718, compound → HCID 57667915, compound

HRID 2191834Notes

Reaction equation

HRID 2191834 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH:10][C:11]3[CH:23]=[C:22]([CH2:24][CH2:25][C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([O:32][CH3:33])[CH:27]=4)[CH:21]=[CH:20][C:12]=3[C:13]([O:15]C(C)(C)C)=[O:14])=[CH:9][C:4]=2[CH:3]=[CH:2]1>FC(F)(F)C(O)=O>[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH:10][C:11]3[CH:23]=[C:22]([CH2:24][CH2:25][C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([O:32][CH3:33])[CH:27]=4)[CH:21]=[CH:20][C:12]=3[C:13]([OH:15])=[O:14])=[CH:9][C:4]=2[CH:3]=[CH:2]1

Participants

3

Reactant 1

HCID 68958718HCID 68958718, compound

Product 1

HCID 57667915HCID 57667915, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Trifluoroacetic acid 10 mL was added to the obtained tert-butyl 2-((benzothiophen-5-yl)amino)-4-(2-(3-methoxyphenyl)ethyl)benzoate, and it was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure,diisopropyl ether was added to the obtained residue, and solid matter was filtrated to give 2-((benzothiophen-5-yl)amino)-4-(2-(3-methoxyphenyl)ethyl)benzoic acid 61 mg of a brown solid.

Workup

  1. customThe solvent was removed under reduced pressure,diisopropyl ether
  2. additionwas added to the obtained residue, and solid matter
  3. filtrationwas filtrated

Sources & evidence

ORD record
ord-80cfe55eb0f3417db54dea5b1547a76e
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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