Trifluoroacetic acid → HCID 57668071, compound

HRID 2191845Notes

Reaction equation

HRID 2191845 reaction equation
FC(F)(F)C(O)=O.[C:8]1([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH:13]=[CH:12][C:11]([NH:14][C:15]2[CH:27]=[C:26]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH:25]=[CH:24][C:16]=2[C:17]([O:19]C(C)(C)C)=[O:18])=[CH:10][CH:9]=1>ClCCl>[C:8]1([C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH:13]=[CH:12][C:11]([NH:14][C:15]2[CH:27]=[C:26]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH:25]=[CH:24][C:16]=2[C:17]([OH:19])=[O:18])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68960063HCID 68960063, compound

Product 1

HCID 57668071HCID 57668071, compoundYield 71.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid 2.5 mL was added to dichloromethane 2.5 mL solution of tert-butyl 2-((biphenyl-4-yl)amino)-4-phenylbenzoate 84 mg, and it was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure,diisopropyl ether was added to the obtained residue, and solid matter was filtrated to give 2-((biphenyl-4-yl)amino)-4-phenylbenzoic acid 52 mg of a yellow solid.

Workup

  1. customThe solvent was removed under reduced pressure,diisopropyl ether
  2. additionwas added to the obtained residue, and solid matter
  3. filtrationwas filtrated

Sources & evidence

ORD record
ord-d0c6a4e3547744b083afd748fa5583da
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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