Trifluoroacetic acid → 2-((3-(Acetamido)phenyl)amino)-4-phenethylbenzoic acid

HRID 2191849Notes

Reaction equation

HRID 2191849 reaction equation
FC(F)(F)C(O)=O.[C:8]([NH:11][C:12]1[CH:13]=[C:14]([NH:18][C:19]2[CH:31]=[C:30]([CH2:32][CH2:33][C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[CH:29]=[CH:28][C:20]=2[C:21]([O:23]C(C)(C)C)=[O:22])[CH:15]=[CH:16][CH:17]=1)(=[O:10])[CH3:9]>>[C:8]([NH:11][C:12]1[CH:13]=[C:14]([NH:18][C:19]2[CH:31]=[C:30]([CH2:32][CH2:33][C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[CH:29]=[CH:28][C:20]=2[C:21]([OH:23])=[O:22])[CH:15]=[CH:16][CH:17]=1)(=[O:10])[CH3:9]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68965181Tert-butyl 2-((3-(acetamido)phenyl)amino)-4-phenethylbenzoate

Product 1

HCID 576680642-((3-(Acetamido)phenyl)amino)-4-phenethylbenzoic acid

Procedure

Trifluoroacetic acid 7.5 mL was added to the obtained tert-butyl 2-((3-(acetamido)phenyl)amino)-4-phenethylbenzoate, and it was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure,diisopropyl ether was added to the obtained residue, and solid matter was filtrated to give 2-((3-(acetamido)phenyl)amino)-4-phenethylbenzoic acid 0.12 g of a white solid.

Workup

  1. customThe solvent was removed under reduced pressure,diisopropyl ether
  2. additionwas added to the obtained residue, and solid matter
  3. filtrationwas filtrated

Sources & evidence

ORD record
ord-319a32eefea24ba58d0db7100769058f
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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