Trifluoroacetic acid → HCID 57668029, compound

HRID 2191853Notes

Reaction equation

HRID 2191853 reaction equation
FC(F)(F)C(O)=O.[C:8]([NH:11][C:12]1[CH:13]=[C:14]([NH:18][C:19]2[CH:31]=[C:30]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[CH:29]=[CH:28][C:20]=2[C:21]([O:23]C(C)(C)C)=[O:22])[CH:15]=[CH:16][CH:17]=1)(=[O:10])[CH3:9]>>[C:8]([NH:11][C:12]1[CH:13]=[C:14]([NH:18][C:19]2[CH:31]=[C:30]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[CH:29]=[CH:28][C:20]=2[C:21]([OH:23])=[O:22])[CH:15]=[CH:16][CH:17]=1)(=[O:10])[CH3:9]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68958760HCID 68958760, compound

Product 1

HCID 57668029HCID 57668029, compound

Procedure

Trifluoroacetic acid 7.5 mL was added to the obtained tert-butyl 2-((3-(acetamido)phenyl)amino)-4-phenylbenzoate, and it was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure,diisopropyl ether was added to the obtained residue, and solid matter was filtrated to give 2-((3-(acetamido)phenyl)amino)-4-phenylbenzoic acid 0.13 g of a yellow solid.

Workup

  1. customThe solvent was removed under reduced pressure,diisopropyl ether
  2. additionwas added to the obtained residue, and solid matter
  3. filtrationwas filtrated

Sources & evidence

ORD record
ord-95f56c2d1f294776b800d9323f4c237d
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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