Hydrazine hydrate (1:1) → HCID 23016677, compound

HRID 2191898Notes

Reaction equation

HRID 2191898 reaction equation
O.[NH2:2][NH2:3].Cl[C:5]1[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][N:8]=[C:7]([S:16][CH3:17])[N:6]=1>C(O)C>[NH:2]([C:5]1[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][N:8]=[C:7]([S:16][CH3:17])[N:6]=1)[NH2:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 800084-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester

Product 1

HCID 23016677HCID 23016677, compoundYield 65.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Conditions

Temperature
0 °C

Procedure

To a solution of hydrazine monohydrate (9.71 g) dissolved in ethanol (200 mL) and cooled at 0° C., added was a solution of ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate (15.0 g) dissolved in ethanol (200 mL), and stirred for 1 hour. The precipitated solid was collected through filtration, washed with distilled water and dried to give the entitled compound as a white solid (9.66 g).

Workup

  1. additionadded
  2. filtrationThe precipitated solid was collected through filtration
  3. washwashed with distilled water
  4. customdried

Sources & evidence

ORD record
ord-641ee1acf8b7458fb5a0c1fa8d23370b
Source dataset
uspto-grants-2012_12
Patent number
US08329711B2

Reaction notes

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