反应详情

Tetra-n-butylammonium bromide (1.5 g), 1,2-dibromoethane (6.5 g) and aqueous 50% sodium hydroxide solution (20 mL) were added to a toluene (40 mL) solution of methyl 2-cyanophenylacetate (4.0 g), and stirred at room temperature for 1 hour. Water was added to the reaction liquid, and extracted with ethyl acetate. The organic layer was washed with saturated saline water, then dried with anhydrous magnesium sulfate, and the solvent was evaporated away under reduced pressure. The crude product was purified through silica gel column chromatography (hexane/ethyl acetate) to give the entitled compound as a colorless solid (3.0 g).

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with saturated saline water
3. dry with materialdried with anhydrous magnesium sulfate
4. customthe solvent was evaporated away under reduced pressure
5. customThe crude product was purified through silica gel column chromatography (hexane/ethyl acetate)