HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Methylpiperidin-4-ol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 1-Boc-4-methyl-piperidin-4-OL | HCID 22730812 | — |
| Product | 4-Methylpiperidin-4-ol hydrochloride | HCID 21949295 | — |
Reaction Steps
To tert-butyl 4-hydroxy-4-methylpiperidine-1-carboxylate (1.0 g, 4.6 mmol) was added hydrogen chloride, 1.0 M solution in diethyl ether (4.6 ml, 4.6 mmol). The reaction mixture was stirred at RT for 4 h. The reaction mixture was concentrated down to give a yellow oil which was used directly in the following step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329700B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-539a5e7c6c594e2db9d5d9c4f046b95e |
| Source note | uspto-grants-2012_12 |