Hydrochloric Acid → 4-Methylpiperidin-4-ol hydrochloride

HRID 2191934Notes

Reaction equation

HRID 2191934 reaction equation
[OH:1][C:2]1([CH3:15])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.[ClH:16].C(OCC)C>>[ClH:16].[CH3:15][C:2]1([OH:1])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 227308121-Boc-4-methyl-piperidin-4-OL

Product 1

HCID 219492954-Methylpiperidin-4-ol hydrochloride

Procedure

To tert-butyl 4-hydroxy-4-methylpiperidine-1-carboxylate (1.0 g, 4.6 mmol) was added hydrogen chloride, 1.0 M solution in diethyl ether (4.6 ml, 4.6 mmol). The reaction mixture was stirred at RT for 4 h. The reaction mixture was concentrated down to give a yellow oil which was used directly in the following step.

Workup

  1. concentrationThe reaction mixture was concentrated down
  2. customto give a yellow oil which

Sources & evidence

ORD record
ord-539a5e7c6c594e2db9d5d9c4f046b95e
Source dataset
uspto-grants-2012_12
Patent number
US08329700B2

Reaction notes

Loading…