反应详情

8 ml of 1N aqueous sodium hydroxide solution are added to a solution of 637 mg (1.70 mmol) of N-{4-[(3-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]-3-fluorophenyl}-2,2,2-trifluoroacetamide in tetrahydrofuran (10 ml). The reaction is stirred overnight. The solution is extracted with ethyl acetate (two times 20 ml). The combined organic phases are washed with a saturated sodium chloride solution. The organic phase is dried over magnesium sulfate and concentrated. This gives a solid which is not purified any further.

1. extractionThe solution is extracted with ethyl acetate (two times 20 ml)
2. washThe combined organic phases are washed with a saturated sodium chloride solution
3. dry with materialThe organic phase is dried over magnesium sulfate
4. concentrationconcentrated
5. customThis gives a solid which
6. customis not purified any further