反应详情

67 mg (0.24 mmol) of 3-fluoro-4-[(3-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]aniline and 40 mg (0.24 mmol) of 4,6-dichloropyrimidine-2-amine are suspended in 4 ml of water/ethanol 1:1. 25 μl (0.29 mmol) of 37% strength hydrochloric acid are added, and the mixture is heated at reflux overnight. Using 1N aqueous sodium hydroxide solution, the pH is adjusted to 7 and the mixture is extracted with ethyl acetate. The organic phase is washed with saturated sodium chloride solution, dried with magnesium sulfate and concentrated. The residue is purified by preparative HPLC.

1. temperaturethe mixture is heated
2. temperatureat reflux overnight
3. extractionthe mixture is extracted with ethyl acetate
4. washThe organic phase is washed with saturated sodium chloride solution
5. dry with materialdried with magnesium sulfate
6. concentrationconcentrated
7. customThe residue is purified by preparative HPLC