反应详情

56 mg (0.17 mmol) of 2-[4-(4-amino-2-fluorophenoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl]ethanol and 30 mg (0.18 mmol) of 4,6-dichloropyrimidine-2-amine are suspended in 5 ml of water. 25 μl of 37% strength hydrochloric acid are added, and the mixture is heated at reflux overnight. Using 1N aqueous sodium hydroxide solution, the pH is then adjusted to 10, resulting in the precipitation of crystals. The mixture is concentrated and filtered through silica gel. The product is purified by preparative HPLC.

1. temperaturethe mixture is heated
2. temperatureat reflux overnight
3. customresulting in the precipitation of crystals
4. concentrationThe mixture is concentrated
5. filtrationfiltered through silica gel
6. customThe product is purified by preparative HPLC