4,6-Dichloropyrimidine → 3-bromo-1-(6-chloropyrimidin-4-yl)-6-(4-methoxyphenyl)-1H-indole

HRID 2192254Notes

Reaction equation

HRID 2192254 reaction equation
[Br:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)=[CH:8][CH:9]=2)[NH:4][CH:3]=1.[Cl:19][C:20]1[CH:25]=[C:24](Cl)[N:23]=[CH:22][N:21]=1>>[Br:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]3[CH:12]=[CH:13][C:14]([O:17][CH3:18])=[CH:15][CH:16]=3)=[CH:8][CH:9]=2)[N:4]([C:24]2[CH:25]=[C:20]([Cl:19])[N:21]=[CH:22][N:23]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 709434,6-DichloropyrimidineHCID 669550543-bromo-6-(4-methoxyphenyl)-1H-indole

Product 1

HCID 509915463-bromo-1-(6-chloropyrimidin-4-yl)-6-(4-methoxyphenyl)-1H-indole

Procedure

The target compound was prepared as in Example 9 using 3-bromo-6-(4-methoxyphenyl)-1H-indole (500 mg, 1.65 mmol) and 4,6-dichloropyrimidine (247 mg, 1.65 mmol).

Sources & evidence

ORD record
ord-427bb462aaae4ce8914d073ace23c6f1
Source dataset
uspto-grants-2012_12
Patent number
US08329708B2

Reaction notes

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