反应详情

To a mixture of benzo[d]isoxazol-3-ylamine (1 g) and cesium carbonate (2.42 g) in dry DMF (20 mL), stirred at rt, was added bromoacetyl chloride (0.62 mL) by dropwise addition. After stirring the mixture for 8 hours, the reaction was poured into water (100 mL) and the products extracted into ether (2×200 mL). The combined extracts were dried over magnesium sulfate and concentrated to dryness. The crude product was purified on silica gel using ether/isohexane (4/6) to afford the sub-titled compound as a colourless solid (0.5 g).

1. additionby dropwise addition
2. stirringAfter stirring the mixture for 8 hours
3. extractionthe products extracted into ether (2×200 mL)
4. dry with materialThe combined extracts were dried over magnesium sulfate
5. concentrationconcentrated to dryness
6. customThe crude product was purified on silica gel