Chloroacetyl chloride → 2-chloro-N-(5-chloropyridin-2-yl)acetamide

HRID 2192371Notes

Reaction equation

HRID 2192371 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.[Cl:9][CH2:10][C:11](Cl)=[O:12]>>[Cl:9][CH2:10][C:11]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1)=[O:12]

Participants

3

Reactant 2

HCID 6577Chloroacetyl chlorideHCID 661742-Amino-5-chloropyridine

Product 1

HCID 51511482-chloro-N-(5-chloropyridin-2-yl)acetamideYield 20%

Procedure

The sub-titled compound (0.33 g, 20%) was prepared by a similar procedure to that used to prepare Example 14f using 2-amino-5-chloropyridine in place of 2-amino-pyridine and adding the chloroacetyl chloride at room temperature rather than at 0° C.

Workup

  1. customto prepare Example 14f

Sources & evidence

ORD record
ord-2cfd4a9fd5554bcc970b216912d7323c
Source dataset
uspto-grants-2012_12
Patent number
US08329729B2

Reaction notes

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