Chloroacetyl chloride → 2-Chloro-N-pyrimidin-2-yl-acetamide
Reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.C(N(CC)CC)C.[Cl:15][CH2:16][C:17](Cl)=[O:18]>ClCCl>[Cl:15][CH2:16][C:17]([NH:1][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1)=[O:18]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 2 amino-pyrimidine (2.0 g) in dry dichloromethane (17 mL) under nitrogen at 0° C. was treated with triethylamine (2.6 mL) followed by slow addition of chloroacetyl chloride (1.5 mL 18.4 mmol). The reaction mixture was allowed to warm up to room temperature. After 2h, the mixture was partitioned between dichioromethane and water.
Workup
- customAfter 2h, the mixture was partitioned between dichioromethane and water
Sources & evidence
- ORD record
- ord-c9feae738e964b54bc5b303038c6113d
- Source dataset
- uspto-grants-2012_12
- Patent number
- US08329729B2
Reaction notes
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