tert-Butyl piperazine-1-carboxylate → HCID 58149909, compound

HRID 2192473Notes

Reaction equation

HRID 2192473 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([C:12]3[N:16]=[C:15]([C:17]4[CH:22]=[CH:21][C:20]([O:23][CH:24]([CH3:26])[CH3:25])=[C:19]([Cl:27])[CH:18]=4)[O:14][N:13]=3)[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[N:28]1([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>C(O)CCC>[Cl:27][C:19]1[CH:18]=[C:17]([C:15]2[O:14][N:13]=[C:12]([C:7]3[CH:8]=[CH:9][CH:10]=[C:11]4[C:6]=3[CH:5]=[CH:4][N:3]=[C:2]4[N:31]3[CH2:30][CH2:29][N:28]([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[CH2:33][CH2:32]3)[N:16]=2)[CH:22]=[CH:21][C:20]=1[O:23][CH:24]([CH3:26])[CH3:25]

Participants

4

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 58149900HCID 58149900, compound

Product 1

HCID 58149909HCID 58149909, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

1-Chloro-5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline (D7; 50 mg), 1,1-dimethylethyl 1-piperazinecarboxylate (93 mg) and n-butanol (0.5 ml) were heated under microwave irradiation at 180° C. for 1 h. After cooling the reaction mixture was filtered and the title compound was isolated as a white solid (24 mg).

Workup

  1. temperatureAfter cooling the reaction mixture
  2. filtrationwas filtered

Sources & evidence

ORD record
ord-870251a02f544563b5288a6a26c11ace
Source dataset
uspto-grants-2012_12
Patent number
US08329730B2

Reaction notes

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