反应详情

1,1-Dimethylethyl 3-[5-(5-{3-chloro-4-[(2,2,2-trifluoroethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]propanoate (D47; 55 mg, 0.103 mmol) was dissolved in 4N HCl in 1,4-dioxane (4 ml) and the solution allowed to stand at room temperature for 2 h. A white precipitate was formed which was filtered off, washed with dry ether and dried to give the title compound as a white solid (33 mg)

1. customA white precipitate was formed which
2. filtrationwas filtered off
3. washwashed with dry ether
4. customdried