Lithium Hydroxide → HCID 59226535, compound

HRID 2192612Notes

Reaction equation

HRID 2192612 reaction equation
[NH2:1][C:2]1[C:3]([C:16]([O-:18])=[O:17])=[N:4][C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[F:15])=[C:6]([F:8])[CH:7]=1.[Li+].[OH-]>>[NH2:1][C:2]1[C:3]([C:16]([OH:18])=[O:17])=[N:4][C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[F:15])=[C:6]([F:8])[CH:7]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 86639731HCID 86639731, compound

Product 1

HCID 59226535HCID 59226535, compoundYield 90%

Procedure

Method 2 was followed using 3-amino-5-fluoro-6-(2-fluorophenyl)picolinate (1.0 equiv.) and LiOH (5.0 equiv.) to give 3-amino-5-fluoro-6-(2-fluorophenyl)picolinic acid in 90% yield. LC/MS=251.1 (M+H), Rt=0.80 min.

Sources & evidence

ORD record
ord-1f903360055d466c9ed69a7fb08f6891
Source dataset
uspto-grants-2012_12
Patent number
US08329732B2

Reaction notes

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