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HRID2192658

反应详情

EQUATION

反应方程式

HRID 2192658 反应方程式

REACTANTS

反应物

2
6-Bromo-5-fluoropyridine-2-carboxylic acid 分子结构式
HCID53401194

6-Bromo-5-fluoropyridine-2-carboxylic acid

C6H3BrFNO2

HCID 67130847 分子结构式
HCID67130847

未命名化合物

PRODUCTS

产物

1
HCID 59226530 分子结构式
HCID59226530

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
Ethyl Acetate 分子结构式
溶剂HCID8857

Ethyl Acetate

C4H8O2

PROCEDURE

实验过程

Following Method 9, 4-(3-(tert-butyldimethylsilyloxy)-5-methylcyclohex-1-enyl)pyridin-3-amine and 6-bromo-5-fluoropicolinic acid were coupled and following addition of EtOAc and washing with H2O, NaCl(sat.) and drying over MgSO4, 6-bromo-N-(4-(3-(tert-butyldimethylsilyloxy)-5-methylcyclohex-1-enyl)pyridin-3-yl)-5-fluoropicolinamide was obtained. LCMS (m/z): 455.3 (MH+); LC Rt=2.09 min.

WORKUP

后处理

  1. washwashing with H2O, NaCl(sat.)
  2. dry with materialdrying over MgSO4