HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 59226443, compound → HCID 86639734, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 59226443 | HCID 59226443 | — |
| Reactant | 3-Amino-6-bromo-5-fluoropicolinic acid | HCID 72698879 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86639734 | HCID 86639734 | — |
Reaction Steps
Following Method 9, 2-(3-(3-aminopyridin-4-yl)cyclohexyl)-isoindoline-1,3-dione and 3-amino-6-bromo-5-fluoropicolinic acid were coupled and following addition of EtOAc and washing with H2O, NaCl(sat.) and drying over MgSO4, 3-amino-6-bromo-N-(4-((1R,3S)-3-(1,3-dioxoisoindolin-2-yl)cyclohexyl)pyridin-3-yl)-5-fluoropicolinamide was obtained. LCMS (m/z): 538.1/540.1 (MH); LC Rt=3.46 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329732B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-040eda0679404b3ab6158560ce699d7a |
| Source note | uspto-grants-2012_12 |