huagongshe.com
HRID2192660

反应详情

EQUATION

反应方程式

HRID 2192660 的结构方程式

REACTANTS

反应物

2
结构：Nc1cnccc1C1CCCC(N2C(=O)c3ccccc3C2=O)C1
HCID59226443

未命名化合物

结构：Nc1cc(F)c(Br)nc1C(=O)O
HCID72698879

3-Amino-6-bromo-5-fluoro-2-pyridinecarboxylic acid

C6H4BrFN2O2

PRODUCTS

生成物

1
结构：Nc1cc(F)c(Br)nc1C(=O)Nc1cnccc1[C@@H]1CCC[C@H](N2C(=O)c3ccccc3C2=O)C1
HCID86639734

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Following Method 9, 2-(3-(3-aminopyridin-4-yl)cyclohexyl)-isoindoline-1,3-dione and 3-amino-6-bromo-5-fluoropicolinic acid were coupled and following addition of EtOAc and washing with H2O, NaCl(sat.) and drying over MgSO4, 3-amino-6-bromo-N-(4-((1R,3S)-3-(1,3-dioxoisoindolin-2-yl)cyclohexyl)pyridin-3-yl)-5-fluoropicolinamide was obtained. LCMS (m/z): 538.1/540.1 (MH); LC Rt=3.46 min.

WORKUP

后处理

  1. washwashing with H2O, NaCl(sat.)
  2. dry with materialdrying over MgSO4