HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → HCID 25029744, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | HCID 67293724 | HCID 67293724 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 25029744 | HCID 25029744 | — |
Reaction Steps
16.05 g (71.04 mmol) of 2-(4-fluorobenzylamino)malonamide are refluxed with 71 ml of triethyl orthoformate, i.e. 6 equivalents, and a catalytic amount of PTSA (250 mg) in 535 ml of absolute ethanol, in a round-bottomed flask placed under argon.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329738B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-41f9d3fd97984880bf2b53807e7ccce0 |
| Source note | uspto-grants-2012_12 |