5-Nitrobenzimidazole → HCID 178507353, compound

HRID 2192684Notes

Reaction equation

HRID 2192684 reaction equation
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]2[N:8]=[CH:9][NH:10][C:6]=2[CH:5]=1)([O-])=O>CO.[Pd]>[NH:8]1[C:7]2[CH:11]=[CH:12][C:4]([NH2:1])=[CH:5][C:6]=2[N:10]=[CH:9]1

Participants

4

Reactant 1

HCID 71955-Nitrobenzimidazole

Product 1

HCID 178507353HCID 178507353, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 5-nitrobenzimidazole (10.0 g, 613 mmol) in methanol (250 mL) was hydrogenated in the presence of 10% Pd/C (0.40 g) at atmospheric pressure for 20 h. The mixture was filtered through Celite® and the solvent removed under reduced pressure to afford the pure product (8.1 g, 100%).

Workup

  1. filtrationThe mixture was filtered through Celite®
  2. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-e0d76ab6f3bf4b7e8fa053a7f21fe6e1
Source dataset
uspto-grants-2012_12
Patent number
US08329737B2

Reaction notes

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