Hydrogen chloride-ethyl acetate → HCID 68432360, compound

HRID 2192784Notes

Reaction equation

HRID 2192784 reaction equation
[CH2:1]([CH:3]1[N:8]([C:9]([C:11]2[C:12]([NH:20][CH2:21][C:22]3[O:23][CH:24]=[CH:25][CH:26]=3)=[N:13][C:14]([CH:17]([CH3:19])[CH3:18])=[N:15][CH:16]=2)=[O:10])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1)[CH3:2].C(OCC)(=O)C.[ClH:40]>>[ClH:40].[ClH:40].[CH2:1]([CH:3]1[CH2:4][NH:5][CH2:6][CH2:7][N:8]1[C:9]([C:11]1[C:12]([NH:20][CH2:21][C:22]2[O:23][CH:24]=[CH:25][CH:26]=2)=[N:13][C:14]([CH:17]([CH3:19])[CH3:18])=[N:15][CH:16]=1)=[O:10])[CH3:2]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59625271HCID 59625271, compound

Product 1

HCID 68432360HCID 68432360, compound

Procedure

tert-Butyl 3-ethyl-4-({4-[(2-furylmethyl)amino]-2-isopropylpyrimidin-5-yl}carbonyl)piperazine-1-carboxylate (100 mg) was dissolved in 4 M hydrogen chloride-ethyl acetate solution (3 ml), and the mixture was stirred at room temperature for 15 hr. The reaction mixture was concentrated under reduced pressure, ethyl acetate was added and the precipitate was collected by filtration to give the object compound (74 mg).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure, ethyl acetate
  2. additionwas added
  3. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-fcd370ca5ba44e3692a1a45725e3a3bf
Source dataset
uspto-grants-2012_12
Patent number
US08329691B2

Reaction notes

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