Hydrogen chloride-ethyl acetate → 2-tert-butyl-4-[(3-methoxypropyl)amino]-N-(2-methylpropyl)-N-[(3S,5R)-5-(morpholin-4-ylcarbonyl)piperidin-3-yl]pyrimidine-5-carboxamide dihydrochloride

Participants

Reaction Steps

tert-Butyl (3S,5R)-3-[({2-tert-butyl-4-[(3-methoxypropyl)amino]pyrimidin-5-yl}carbonyl)(isobutyl)amino]-5-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate (105 mg) is was dissolved in 1 M hydrogen chloride-ethyl acetate (6 ml), and the mixture was stirred at room temperature for 13 hr. The reaction mixture was concentrated to give the object compound (93 mg).

Provenance & Evidence