反应详情

1-tert-Butyl 3-methyl (3R,5S)-5-[(2-methylpropyl)amino]piperidine-1,3-dicarboxylate (3.0 g) was dissolved in THF (30 ml), a solution (15.2 ml) of 3 M pentamethylenebis(magnesium bromide) in THF was added dropwise under ice-cooling, and the mixture was stirred at room temperature for 3 hr. 2 N Aqueous ammonium chloride solution (50 ml) was added to the reaction solution under ice-cooling, and the mixture was extracted with ethyl acetate, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was subjected to basic silica gel column chromatography, and the fraction eluted with ethyl acetate-hexane (0:10→10:0) was concentrated under reduced pressure to give the object compound (1.3 mg).

1. temperaturecooling
2. temperaturecooling
3. extractionthe mixture was extracted with ethyl acetate
4. dry with materialdried over anhydrous magnesium sulfate
5. customThe solvent was evaporated under reduced pressure
6. washthe fraction eluted with ethyl acetate-hexane (0:10→10:0)
7. concentrationwas concentrated under reduced pressure