Hydrochloride methanol → HCID 68432464, compound

HRID 2192851Notes

Reaction equation

[C:1]([C:5]1[N:10]=[C:9]([NH:11][CH2:12][CH2:13][CH2:14][O:15][CH3:16])[C:8]([C:17]([N:19]([CH2:43][CH:44]([CH3:46])[CH3:45])[C@H:20]2[CH2:25][C@@H:24]([C:26]([N:28]3[CH2:33][CH2:32][C:31]([OH:35])([CH3:34])[CH2:30][CH2:29]3)=[O:27])[CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21]2)=[O:18])=[CH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].[ClH:47].CO>>[ClH:47].[ClH:47].[C:1]([C:5]1[N:10]=[C:9]([NH:11][CH2:12][CH2:13][CH2:14][O:15][CH3:16])[C:8]([C:17]([N:19]([C@H:20]2[CH2:25][C@@H:24]([C:26]([N:28]3[CH2:33][CH2:32][C:31]([OH:35])([CH3:34])[CH2:30][CH2:29]3)=[O:27])[CH2:23][NH:22][CH2:21]2)[CH2:43][CH:44]([CH3:46])[CH3:45])=[O:18])=[CH:7][N:6]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 21893726Hydrochloride methanol

HCID 59625477HCID 59625477, compound

Product 1

HCID 68432464HCID 68432464, compound

Procedure

tert-Butyl (3S,5R)-3-[({2-tert-butyl-4-[(3-methoxypropyl)amino]pyrimidin-5-yl}carbonyl)(2-methylpropyl)amino]-5-[(4-hydroxy-4-methylpiperidin-1-yl)carbonyl]piperidine-1-carboxylate (113 mg) was dissolved in 10% hydrogen chloride-methanol solution (4.5 ml), and the mixture was stirred at room temperature for 18 hr. The solvent was evaporated under reduced pressure, and the residue was dried under reduced pressure to give the object compound (82 mg).

Workup

customThe solvent was evaporated under reduced pressure
customthe residue was dried under reduced pressure

Sources & evidence

ORD record: ord-08642e5f043640aa8a96b9acaea482ab
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08329691B2

Reaction notes

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